Book chapter
Linking Chromosome Duplication and Segregation via Sister Chromatid Cohesion
Cell Cycle Control
14 May 2014
PMID: 24906310
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
DNA replication during S phase generates two identical copies of each chromosome. Each chromosome is destined for a daughter cell, but each daughter must receive one and only one copy of each chromosome. To ensure accurate chromosome segregation, eukaryotic cells are equipped with a mechanism to pair the chromosomes during chromosome duplication and hold the pairs until a bi-oriented mitotic spindle is formed and the pairs are pulled apart. This mechanism is known as sister chromatid cohesion, and its actions span the entire cell cycle. During G1, before DNA is copied during S phase, proteins termed cohesins are loaded onto DNA. Paired chromosomes are held together through G2 phase, and finally the cohesins are dismantled during mitosis. The processes governing sister chromatid cohesion ensure that newly replicated sisters are held together from the moment they are generated to the metaphase–anaphase transition, when sisters separate.
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Details
- Title
- Linking Chromosome Duplication and Segregation via Sister Chromatid Cohesion
- Creators
- Adam R Leman - Duke Center for Systems Biology, Duke University, Durham, USAEishi Noguchi - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, USA
- Publication Details
- Cell Cycle Control
- Series
- Methods in Molecular Biology
- Publisher
- Springer New York; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000338508500006
- Scopus ID
- 2-s2.0-84958761574
- Other Identifier
- 991014877925304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology