Book chapter
Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity
Progress in brain research, v 161, pp 27-39
2007
PMID: 17618968
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traumatic brain injury (TBI) represents one of most common disorders to the central nervous system (CNS). Despite significant efforts, though, an effective clinical treatment for TBI is not yet available. The complexity of human TBI is modeled with a broad group of experimental models, with each model matching some aspect of the human condition. In the past 15 years, these in vivo models were complemented with a group of in vitro models, with these in vitro models allowing investigators to more precisely identify the mechanism(s) of TBI, the different intracellular events that occur in acute period following injury, and the possible treatment of this injury in vitro. In this paper, we review the available in vitro models to study TBI, discuss their biomechanical basis for human TBI, and review the findings from these in vitro models. Finally, we synthesize the current knowledge and point out possible future directions for this group of models, especially in the effort toward developing new therapies for the traumatically brain injured patient.
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Details
- Title
- Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity
- Creators
- Jennifer M Spaethling - Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104-6392, USADonna M Geddes-Klein - University of PennsylvaniaWilliam J MillerCatherine R von Reyn - University of PennsylvaniaPallab Singh - University of PennsylvaniaMahlet MesfinSteven J Bernstein - University of PennsylvaniaDavid F Meaney - University of Pennsylvania
- Publication Details
- Progress in brain research, v 161, pp 27-39
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- NS-35712 / NINDS NIH HHS R01 HD-41699 / NICHD NIH HHS
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000251295200003
- Scopus ID
- 2-s2.0-34347348974
- Other Identifier
- 991019520115104721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences