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Microbiome Data Mining for Microbial Interactions and Relationships
Book chapter   Open access

Microbiome Data Mining for Microbial Interactions and Relationships

Xingpeng Jiang and Xiaohua Hu
Big Data Analytics, pp 221-235
13 Oct 2016
url
https://doi.org/10.1007/978-81-322-3628-3_12View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Canonical Correlation Analysis Flux Balance Analysis Microbial Community Microbial Interaction Nonnegative Matrix Factorization
The study of how microbial species coexist and interact in a host-associated environment or a natural environment is crucial to advance basic microbiology science and the understanding of human health and diseases. Researchers have started to infer common interspecies interactions and species–phenotype relations such as competitive and cooperative interactions leveraging to big microbiome data. These endeavors have facilitated the discovery of previously unknown principles of microbial world and expedited the understanding of the disease mechanism. In this review, we will summarize current computational efforts in microbiome data mining for discovering microbial interactions and relationships including dimension reduction and data visualization, association analysis, microbial network reconstruction, as well as dynamic modeling and simulations.

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