Book chapter
Microtubule–Actin Interactions During Neuronal Development
Neurobiology of Actin, pp.73-96
Advances in Neurobiology, Springer New York
18 Oct 2010
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuronal development involves many morphological changes and events that are intimately dependent upon microtubules. These include neuronal migration, axonal and dendritic differentiation, growth, and branching, the navigation of the axon to its target, and the retraction of overgrown axons. Within the various compartments of developing neurons, microtubules take on a variety of different lengths and configurations, and undergo behaviors such as dynamic assembly and disassembly, stabilization, and transport. A growing body of evidence suggests that the microtubule behaviors that underlie neuronal morphogenesis may be regulated in part by interactions of the microtubules with the actin cytoskeleton. The purpose of this chapter is to provide an overview of some of these microtubule–actin interactions and to discuss how these interactions may be important during the development of the neuron. The chapter includes discussions on signaling pathways, molecular motor proteins, classical and non-classical microtubule-associated proteins, and +TIPS.
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Details
- Title
- Microtubule–Actin Interactions During Neuronal Development
- Creators
- Kenneth A. Myers - Drexel UniversityPeter W. Baas - Drexel University
- Publication Details
- Neurobiology of Actin, pp.73-96
- Series
- Advances in Neurobiology
- Publisher
- Springer New York; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991019167882504721
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- Biology
- Neurosciences