Book chapter
Mitochondrial Reactive Oxygen Species in Cellular Senescence
Cellular Ageing and Replicative Senescence, pp 169-185
10 May 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mitochondria are central for the maintenance of cellular homeostasis and both cellular dysfunction and aging are linked to mitochondrial dysfunction. Mitochondrial dysfunction is the principle cause of increased levels of reactive oxygen species (ROS) and oxidative stress, which is a key mediator of aging. The cell responds to this stressful stimulus by the induction of the cellular aging-stress response, cellular senescence. Here, we discuss the mechanisms through which mitochondrial ROS promotes senescence. In this context, we will highlight how mitochondrial ROS serves an initiating upstream, or sustaining downstream, role in the induction of senescence. We will also discuss potential interventions to alleviate mitochondrial ROS and delay cellular senescence.
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Details
- Title
- Mitochondrial Reactive Oxygen Species in Cellular Senescence
- Creators
- Timothy Nacarelli - Drexel UniversityClaudio Torres - Drexel UniversityChristian Sell - Drexel University
- Publication Details
- Cellular Ageing and Replicative Senescence, pp 169-185
- Series
- Healthy Ageing and Longevity
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000429064200011
- Other Identifier
- 991019168195404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Geriatrics & Gerontology