Book chapter
Modeling O2-Dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O2 Transport around Arterioles
Oxygen Transport to Tissue XXXII, pp 271-276
28 Feb 2011
PMID: 21445797
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent evidence in the literature suggests that tissues play a greater role than blood in reducing nitrite to NO under ischemic or hypoxic conditions. Our previous mathematical model for coupled NO and O2 transport around an arteriole, modified to include superoxide generation from dysfunctional endothelium, was developed further to include nitrite reductase activity in blood and tissue. Steady-state radial and axial NO and pO2 profiles in the arteriole and surrounding tissue were simulated for different blood flow rates and arterial blood pO2 values. The resulting computer simulations demonstrate that nitrite reductase activity in blood is not a very effective mechanism for conserving NO due to the strong scavenging of NO by hemoglobin. In contrast, nitrite reductase activity in tissue is much more effective in increasing NO bioavailability in the vascular wall and contributes progressively more NO as tissue hypoxia becomes more severe.
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Details
- Title
- Modeling O2-Dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O2 Transport around Arterioles
- Creators
- Donald G Buerk - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, USAKenneth A Barbee - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, USADov Jaron - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, USA
- Publication Details
- Oxygen Transport to Tissue XXXII, pp 271-276
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US; Boston, MA
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000291499500036
- Scopus ID
- 2-s2.0-84934436942
- Other Identifier
- 991014877791004721
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- Web of Science research areas
- Biology
- Medicine, Research & Experimental
- Physiology