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Modeling of Oxygen Transport under Ischemic Blood Flow Conditions
Book chapter

Modeling of Oxygen Transport under Ischemic Blood Flow Conditions

Donald G. Buerk, Pankajam K. Nair, Eric W. Bridges and Roy W. Schubert
Biomedical Engineering IV, pp 63-66
1985

Abstract

Blood flow and oxygen delivery to tissue is reduced following injury, and during many pathological disease states, including stroke, myocardial infarction, peripheral vascular disease and atherosclerosis. Procedures for clinical treatment include hemodilution using isotonic colloid (Dextran) solutions to reduce blood viscosity, improve blood pressure and increase the volumetric blood flow rate. Consequences of hemodilution for oxygen transport to tissue under ischemic blood flow conditions are modeled. Under some conditions, the required increase in flow needed for improved oxygen transport may exceed the reduction in viscosity. The model can be adapted to evaluate hemodilution with artificial blood.

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