Book chapter
Multifaceted Role of Th17 Cells in Psoriatic Disease
Psoriasis and Psoriatic Arthritis, pp 123-132
2018
Abstract
The T-helper 17 (Th17) cell pathway has been linked to multiple autoimmune diseases, including psoriasis and psoriatic arthritis (PsA). Its discovery has revolutionized and deepened our understanding of the pathophysiological mechanisms underpinning these diseases. Consequently, characterization of the Th17 cytokine pathway driven by the interleukin 23 (IL-23)/IL-17 axis and its implications in the pathogenesis of psoriatic disease has not only highlighted shared characteristics between the larger group of spondyloarthropathies, but also raised the intriguing possibility that psoriasis and PsA may represent a spectrum of a single disease state. In this chapter, after a brief clinical overview of psoriatic disease, a detailed discussion of Th17 cells and their signature cytokine profiles, including expression of IL-17, is provided. Subsequently, an in-depth discussion follows of the IL-23/IL-17 axis and its pivotal role in the pathogenesis of psoriatic disease, as evidenced through multiple experimental animal models and human studies. Finally, recent data are discussed to highlight the potential for psoriasis and PsA to be considered phenotypic manifestations along the continuum of a single, overarching disease state.
The T-helper 17 (Th17) cell pathway has been linked to multiple autoimmune diseases, including psoriasis and psoriatic arthritis (PsA). Its discovery has revolutionized and deepened the understanding of the pathophysiological mechanisms underpinning these diseases. This chapter provides a brief clinical overview of psoriatic disease, a detailed discussion of Th17 cells and their signature cytokine profiles, including expression of interleukin 17 (IL-17). Subsequently, an in-depth discussion follows of the IL-23/IL-17 axis and its pivotal role in the pathogenesis of psoriatic disease, as evidenced through multiple experimental animal models and human studies. Finally, recent data are discussed to highlight the potential for psoriasis and PsA to be considered phenotypic manifestations along the continuum of a single, overarching disease state. The diagnosis of PsA is usually based on clinical presentation and features. It is believed that PsA results from a complex interaction between a genetically predisposed individual and immune dysregulation as a result of some environmental exposure or trigger.
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Details
- Title
- Multifaceted Role of Th17 Cells in Psoriatic Disease
- Creators
- Soumya D. Chakravarty
- Contributors
- Siba P. Raychaudhuri (Editor)Smriti K. Raychaudhuri (Editor)Debasis Bagchi (Editor)
- Publication Details
- Psoriasis and Psoriatic Arthritis, pp 123-132
- Publisher
- Routledge
- Edition
- 1
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Other Identifier
- 991021930319404721