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NEDD9
Book chapter

NEDD9

Joy Little and Erica Golemis
Cancer Therapeutic Targets, pp 787-793
09 Apr 2017
DOI: https://doi.org/10.1007/978-1-4419-0717-2_44

Abstract

Aurora-A Biomarker Cancer Centrosome Cilia Crk-associated substrate (CAS) family Crk-associated substrate-related protein (CAS-L) Human enhancer of filamentation 1 (HEF1) Integrin-mediated attachment Metastasis Neural precursor cell expressed developmentally downregulated 9 (NEDD9) Oncogene Preclinical studies Receptor tyrosine kinase signaling SRC and FAK Tumor cell adhesion Tumor cell migration
Neural Precursor Cell Expressed Developmentally Downregulated 9 (NEDD9; also known as HEF1 and CAS-L) is a multi-domain protein that acts as a scaffold to promote the interactions of proteins involved in cell migration, attachment, and cilia formation, among other processes. While NEDD9 has multiple binding partners, Focal Adhesion Kinase (FAK), SRC, and Aurora-A kinase are the most well-studied in regard to their contributions to oncogenesis. NEDD9 has no catalytic activity, but accumulating evidence supports NEDD9 as a potential biomarker for metastatic cancers.

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