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Book chapter
Nanomechanics of the Cartilage Extracellular Matrix
Annual review of materials research, pp 133-168
01 Jan 2011
PMID: 22792042
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cartilage is a hydrated biomacromolecular fiber composite located at the ends of long bones that enables proper joint lubrication, articulation, loading, and energy dissipation. Degradation of extracellular matrix molecular components and changes in their nanoscale structure greatly influence the macroscale behavior of the tissue and result in dysfunction with age, injury, and diseases such as osteoarthritis. Here, the application of the field of nanomechanics to cartilage is reviewed. Nanomechanics involves the measurement and prediction of nanoscale forces and displacements, intra- and intermolecular interactions, spatially varying mechanical properties, and other mechanical phenomena existing at small length scales. Experimental nanomechanics and theoretical nanomechanics have been applied to cartilage at varying levels of material complexity, e.g., nanoscale properties of intact tissue, the matrix associated with single cells, biomimetic molecular assemblies, and individual extracellular matrix biomolecules (such as aggrecan, collagen, and hyaluronan). These studies have contributed to establishing a fundamental mechanism-based understanding of native and engineered cartilage tissue function, quality, and pathology.
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Details
- Title
- Nanomechanics of the Cartilage Extracellular Matrix
- Creators
- Lin Han - MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USAAlan J. Grodzinsky - MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USAChristine Ortiz - Massachusetts Institute of Technology
- Contributors
- D R Clarke (Editor)P Fratzl (Editor)
- Publication Details
- Annual review of materials research, pp 133-168
- Series
- Annual Review of Materials Research
- Publisher
- Annual Reviews; PALO ALTO
- Number of pages
- 36
- Grant note
- R01 EB003805; R01 EB003805-01A1 / NIBIB NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) R37AR033236 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01 AR033236; R01 AR033236-23; R37 AR033236 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01EB003805 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000294028600006
- Scopus ID
- 2-s2.0-79960113159
- Other Identifier
- 991019187089104721
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- Web of Science research areas
- Materials Science, Multidisciplinary