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Book chapter
Neuropathic Pain in Multiple Sclerosis-Current Therapeutic Intervention and Future Treatment Perspectives
01 Jan 2017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic pain is defined as any consistent pain lasting more than 12 weeks; chronic pain afflicts 25% of the world's population. The most common form of chronic pain is chronic neuropathic pain, which affects around 8% of the general population and is defined as pain that is initiated or caused by a primary lesion or dysfunction of the nervous system. Neuropathic pain is commonly associated with a variety of neurodegenerative, metabolic, and autoimmune diseases. In multiple sclerosis (MS), chronic neuropathic pain is one of the most frequent symptoms that dramatically reduces the quality of life of MS patients. Current treatment strategies include antidepressants, anticonvulsants, and -cannabinoid drugs. However, the efficacy of these drugs varies between patients. Besides providing only insufficient relief of pain, these drugs also lead to severe side effects. Therefore, there is an unmet medical need to identify novel drug targets, which may lead to the development of novel therapeutics with enhanced tolerability profiles and efficacy for the management of MS-associated chronic neuropathic pain.
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Details
- Title
- Neuropathic Pain in Multiple Sclerosis-Current Therapeutic Intervention and Future Treatment Perspectives
- Creators
- Kayla L. Murphy - Drexel UniversityJohn R. Bethea - Drexel UniversityRoman Fischer - Drexel University
- Contributors
- I S Zagon (Editor)P J McLaughlin (Editor)
- Publisher
- Codon Publications; WILSHART
- Number of pages
- 17
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000416055100006
- Scopus ID
- 2-s2.0-85215205557
- Other Identifier
- 991019169665704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology