Book chapter
Norepinephrine and Synaptic Transmission in the Cerebellum
Handbook of the Cerebellum and Cerebellar Disorders, pp 895-914
01 Jan 2013
Abstract
Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specific information. As a result of these cellular actions, the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.
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6 citations in Scopus
Details
- Title
- Norepinephrine and Synaptic Transmission in the Cerebellum
- Creators
- Daniel J. Chandler - Drexel UniversityShevon E. Nicholson - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, USAGerard Zitnik - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, USABarry D. Waterhouse - Drexel University
- Publication Details
- Handbook of the Cerebellum and Cerebellar Disorders, pp 895-914
- Publisher
- Springer Netherlands; Dordrecht
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Scopus ID
- 2-s2.0-85015455207
- Other Identifier
- 991019174324804721