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Obesity and Skeletal Mass
Book chapter

Obesity and Skeletal Mass

Sue Shapses and Deeptha Sukumar
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, pp 993-1001
19 Jul 2013

Abstract

adipokines bone marrow fat bone mineral density (BMD) fracture risk obesity skeletal mass weight reduction
Obesity is a national health problem and its prevalence is increasing in developing countries. Obesity may induce changes in bone due to several mechanisms, including an altered hormonal milieu because of factors secreted by adipose tissue, known as adipokines, which may be important mediators in the bone‐fat relationship. Many obese persons have a history of dieting, which may increase fracture risk. Also, adiposity‐induced metabolic alterations, poor dietary intake, sarcopenia, and/or biomechanical disadvantages in obesity may contribute to the risk of fracture in obese children and adults. The benefits of weight reduction in the obese are multiple, and importantly, a higher protein intake, a multivitamin/mineral supplementation, and exercise should be encouraged to increase calcium and other micronutrients that are reduced during dieting to minimize bone loss.

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