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Book chapter
Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV: Methods and Protocols
pp 139-162
01 Jan 2021
PMID: 32975796
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Opioid use has substantially increased over recent years and remains a major driver of new HIV infections worldwide. Clinical studies indicate that opioids may exacerbate the symptoms of HIV-associated neurocognitive disorders (HAND), but the mechanisms underlying opioid-induced cognitive decline remain obscure. We recently reported that the mu-opioid agonist morphine increased neuronal iron levels and levels of ferritin proteins that store iron, suggesting that opioids modulate neuronal iron homeostasis. Additionally, increased iron and ferritin heavy chain protein were necessary for morphine's ability to reduce the density of thin and mushroom dendritic spines in cortical neurons, which are considered critical mediators of learning and memory, respectively. As altered iron homeostasis has been reported in HAND and related neurocognitive disorders like Alzheimer's, Parkinson's, and Huntington's disease, understanding how opioids regulate neuronal iron metabolism may help identify novel drug targets in HAND with potential relevance to these other neurocognitive disorders. Here, we review the known mechanisms of opioidmediated regulation of neuronal iron and corresponding cellular responses and discuss the implications of these findings for patients with HAND. Furthermore, we discuss a new molecular approach that can be used to understand if opioid modulation of iron affects the expression and processing of amyloid precursor protein and the contributions of this pathway to HAND.
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Details
- Title
- Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV
- Creators
- Bradley Nash - Drexel UniversityElena Irollo - Drexel UniversityRenato Brandimarti - Drexel UniversityOlimpia Meucci - Drexel University
- Contributors
- S M Spampinato (Editor)
- Publication Details
- pp 139-162
- Series
- Methods in Molecular Biology
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 24
- Grant note
- DA015014; DA032444; DA040519 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Pharmacology and Physiology
- Web of Science ID
- WOS:000687320100014
- Scopus ID
- 2-s2.0-85091695512
- Other Identifier
- 991019168633204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology
- Pharmacology & Pharmacy