Book chapter
Optical Non-invasive Characterization of Chronic Wounds
pp.381-404
Studies in Mechanobiology Tissue Engineering and Biomaterials, Springer Nature
01 Jan 2009
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The health burden of chronic wounds is increasing at an alarming rate corresponding to the increase in the elderly and diabetic population. It is estimated that approximately 1% of the total health care costs in the western world are likely to be used for the management of chronic leg ulcers. This chapter reviews the optical methodologies that have been used mostly in a pre-clinical, research setting for the characterization of chronic wounds. Chronic wounds include diabetic foot ulcers, venous leg ulcers and pressure ulcers that do not heal within 4 weeks. The technologies covered include:
a) Optical coherence tomography (OCT) for structural imaging of wound tissue.
b) Laser Doppler perfusion imaging for monitoring cutaneous blood flow.
c) Spectroscopic methods for monitoring metabolic status at superficial depths (less than 1 millimeter), such as Diffuse Reflectance Spectroscopy.
d) Spectroscopic methods for monitoring metabolic status deep into the tissue (up to several centimeters of penetration depths) such as Diffuse Photon Density Wave methodology.
e) Hyperspectral imaging for creating two-dimensional maps of spectroscopic data over the surface of the skin.
f) Orthogonal polarization spectral imaging for visualizing cutaneous microcirculation in vivo.
g) Thermal imaging which for measuring the temperature of tissue and correlating it to inflammatory or microcirculation state.
The principles of each methodology are summarized with brief schematics and the key studies that demonstrate the use of each technology in assessing the healing status of chronic wounds in human studies are summarized and discussed.
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Details
- Title
- Optical Non-invasive Characterization of Chronic Wounds
- Creators
- Michael Neidrauer - Drexel UniversityElisabeth S. Papazoglou - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA
- Contributors
- A Gefen (Editor)
- Publication Details
- pp.381-404
- Series
- Studies in Mechanobiology Tissue Engineering and Biomaterials
- Publisher
- Springer Nature; NEW YORK
- Number of pages
- 24
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991019170128004721
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