Book chapter
PREVAIL study
Handbook of the Vulnerable Plaque, pp 469-482
2006
Abstract
Atherosclerotic coronary artery disease
(CAD) is the leading cause of morbidity
and mortality in industrialized countries.1
Clinical manifestations of CAD include
sudden cardiac death and acute coronary
syndromes (ACS) of unstable angina,
non-ST-elevation myocardial infarction
(MI), and ST-elevation MI. Most acute
ischemic events are caused by rupture or
superficial erosion of coronary plaques at
sites with only mild to moderate luminal
stenosis.2 Coronary plaques which are
prone to rupture, the so-called vulnerable
plaques, tend to have a thin fibrous cap
and a large lipid core. Recent data indicate that patients with ACS manifest
multiple ruptured/vulnerable plaques in
addition to the culprit lesion causing the
index ischemic event.3-6 These additional
ruptured plaques may be associated with
a poor long-term prognosis. The significance of this issue is evidenced by the fact
that patients with ACS account for approximately 1.4 million hospitalizations each
year in the USA, and more than 2 million
admissions worldwide.1
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Details
- Title
- PREVAIL study
- Creators
- Sheldon Goldberg - Medicine (Graduate)
- Contributors
- Ron Waksman (Editor)Patrick W Serruys (Editor)Johannes Schaar (Editor)
- Publication Details
- Handbook of the Vulnerable Plaque, pp 469-482
- Publisher
- CRC Press
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Other Identifier
- 991019174891904721