Book chapter
Polyketide Synthase: Sequence, Structure, and Function
Natural Products, pp 219-243
10 Mar 2014
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This chapter describes structural and associated enzymological studies of polyketide synthases. The sequence‐structure‐function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. The structural and functional studies shed light on sequence and structural motifs important for the timing, substrate recognition, enzyme catalysis and protein‐protein interactions leading to the extraordinary structural diversity of naturally‐occurring polyketides.
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Details
- Title
- Polyketide Synthase: Sequence, Structure, and Function
- Creators
- Joel Bruegger - University of California, IrvineGrace Caldara - University of California, IrvineJoris Beld - University of California San DiegoMichael D Burkart - University of California San DiegoShiou‐Chuan (Sheryl) Tsai - University of California, Irvine
- Contributors
- Anne Osbourn (Editor)Rebecca J Goss (Editor)Guy T Carter (Editor)
- Publication Details
- Natural Products, pp 219-243
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ, USA
- Number of pages
- 25
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000467389500012
- Scopus ID
- 2-s2.0-84926454112
- Other Identifier
- 991020535066604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Medicinal