Book chapter
Postsynaptic integration and plasticity in the prefrontal cortex
Handbook of Behavioral Neuroscience, v 32, pp 213-222
2025
Abstract
Dopamine modulation is integral to the normal function of the prefrontal cortex (PFC)—a lack of prefrontal dopamine causes deficits nearly equivalent to removing the PFC altogether. After seminal studies discovered the importance of dopamine to PFC function, there has been an ongoing quest to determine the cellular mechanisms of dopamine modulation in the PFC. Subsequent research, spanning rodents to nonhuman primates, has highlighted how dopamine elicits diverse effects on many aspects of prefrontal circuitry, from intrinsic excitability to synaptic signaling and plasticity. In this chapter, we review the current understanding of dopamine's influence over PFC cell types and circuits and the mechanisms through which these effects are mediated.
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Details
- Title
- Postsynaptic integration and plasticity in the prefrontal cortex
- Creators
- Paul G. Anastasiades - University of BristolGuillermo Gonzalez-Burgos - University of PittsburghWen-Jun Gao - Drexel University
- Publication Details
- Handbook of Behavioral Neuroscience, v 32, pp 213-222
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Scopus ID
- 2-s2.0-105011994339
- Other Identifier
- 991022073152404721