Book chapter
Prebiotics and Lipid Metabolism
Handbook of Prebiotics and Probiotics Ingredients, pp 227-238
2010
Abstract
Coronary heart disease (CHD) is a major cause of morbidity and mortality in
industrialized countries. Several epidemiologic and clinical studies reveal a positive correlation between elevated total serum cholesterol levels, mainly reecting the
low-density lipoprotein (LDL) cholesterol fraction, and risk of CHD.1 Specically,
large-scale epidemiologic surveys suggest that elevated fasting triglyceride levels
are associated with a greater risk of CHD, and that this effect is independent of any
association with high-density lipoprotein (HDL) cholesterol.2 Elevated postprandial
triglyceride concentrations may also predict CHD risk.3,4 Intervention studies have
CONTENTS
10.1 Introduction ...209
10.2 Cholesterol Metabolism ... 210
10.3 Bile Acid Metabolism ... 211
10.4 Probiotics and Lipid Metabolism ... 212
10.5 Prebiotics and Lipid Metabolism ... 213
10.5.1 Experimental (Animal) Studies ... 213
10.5.2 Human Studies ... 214
10.6 Mechanism by Which Prebiotics Exert Their Effect on Lipid
Metabolism ... 215
10.6.1 Effects on Hepatic Cholesterol Synthesis ... 215
10.6.2 Fermentation Products as Mediators of the Systemic Effects ... 215
10.6.3 Increase in Cholesterol Excretion ... 216
10.6.4 Effect on Bacterial Flora ... 216
10.7 Conclusion ... 217
References ... 217
then gone on to prove that reduction in total plasma cholesterol levels in patients with
primary hypercholesterolemia can lower the incidence of coronary thrombosis.5
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Details
- Title
- Prebiotics and Lipid Metabolism
- Creators
- Jonathan E Teitelbaum - Pediatrics
- Contributors
- Susan Sungsoo Cho (Editor)Terry Finocchiaro (Editor)
- Publication Details
- Handbook of Prebiotics and Probiotics Ingredients, pp 227-238
- Publisher
- CRC Press
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pediatrics
- Other Identifier
- 991019174045004721