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RELATIONSHIP BETWEEN CORONARY ARTERY STENOSIS AND LEFT VENTRICULAR ASYNERGY: A COMPUTERIZED STUDY TO EVALUATE LV WALL MOTION
Book chapter

RELATIONSHIP BETWEEN CORONARY ARTERY STENOSIS AND LEFT VENTRICULAR ASYNERGY: A COMPUTERIZED STUDY TO EVALUATE LV WALL MOTION

Barry M. Ethier, David O. Williams, Albert S. Most and Dov Jaron
Proceedings of the Sixth New England Bioengineering Conference, pp 24-28
1978
DOI: https://doi.org/10.1016/B978-0-08-022678-1.50012-6

Abstract

This chapter reviews the relationship between coronary artery stenosis and left ventricular asynergy. Although global left ventricular function can be well quantified, analysis of regional wall motion has been limited mainly for lack of a satisfactory method of measuring segmental motion. Radiographic cine left ventriculography has been used for evaluating left ventricular function. The goals of this investigation were l) to establish a computerized system to quantify left ventricular wall motion and then apply this system to delineate those factors determining ventricular asynergy; and 2) to assess the feasibility of characterizing normal patients from those suffering from single vessel coronary artery stenosis on the basis of that wall motion. In the study described in the chapter, two groups of patients who underwent single plane anterior oblique cine left ventriculography and coronary cineangiography were utilized. One group was composed of 34 patients lacking any significant coronary artery stenosis or other ventricular abnormalities. These were defined to be normal. The second group of 22 patients had significant left anterior descending (LAD) coronary artery stenosis. Data from all patients were stored on magnetic disk and were used through-out the analysis. The results of the study showed that for the ventricular region contained between 30° and 170°, the mean percent change of the chords for normal patients varied between 30% and 40% increasing to mean values varying between 55% and 65% for the region between 190° and 300°. The entire population of LAD patients had significantly reduced percent shortening as compared to normals for left ventricular regions between 60° to 2I5°. In evaluating LAD patients as to the extent of stenosis, those with complete occlusion had greater impairment of shortening than those with stenotic but patent vessels.

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