Book chapter
RETINOBLASTOMA PROTEIN, GENE EXPRESSION, AND CELL CYCLE CONTROL
Cancer Genes, pp 177-191
1995
Abstract
Regulation of cell proliferation is achieved by the tight control of the progression through the cell cycle which controls the transition of cells between quiescent and growing states. This regulation relies on the coordinated balance between inhibitory and stimulatory signals. The stimulatory factors (e.g., growth factors) and their receptors are often encoded by a class of genes called proto-oncogenes. Cells also contain several inhibitory proteins, encoded by tumor suppressor genes which act as either censors or pacers (Marx, 1994).
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Details
- Title
- RETINOBLASTOMA PROTEIN, GENE EXPRESSION, AND CELL CYCLE CONTROL
- Creators
- Jane Clifford Azizkhan - Roswell Park Cancer InstituteShiaw Yih Lin - Roswell Park Cancer InstituteDavid Jensen - The Wistar InstituteDusan Kostic - Roswell Park Cancer InstituteAdrian R. Black - Roswell Park Cancer Institute
- Publication Details
- Cancer Genes, pp 177-191
- Series
- Pezcoller Foundation Symposia
- Publisher
- Springer US; Boston, MA
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Other Identifier
- 991020200890004721