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Book chapter
Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function
Progress in molecular biology and translational science
01 Jan 2015
PMID: 26123303
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Regulators of G protein signaling (RGS) proteins of the B/R4 family are widely expressed in the cardiovascular system where their role in fine-tuning G protein signaling is critical to maintaining homeostasis. Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through G(q/11) and G(i/o) classes of heterotrimeric G proteins. This chapter reviews accumulating evidence supporting a key role for RGS2 in vascular function and the implication of changes in RGS2 function and/or expression in the pathogenesis of blood pressure disorders, particularly hypertension. With such understanding, RGS2 and the signaling pathways it controls may emerge as novel targets for developing next-generation antihypertensive drugs/agents.
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Details
- Title
- Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function
- Creators
- Patrick Osei-Owusu - Drexel UniversityKendall J. Blumer - Washington University in St. Louis
- Contributors
- R A Fisher (Editor)
- Publication Details
- Progress in molecular biology and translational science
- Series
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier; SAN DIEGO
- Number of pages
- 16
- Grant note
- R01HL075632 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01 HL075632; HL075632 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01GM044592 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) GM44592; R01 GM044592 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000385016400006
- Scopus ID
- 2-s2.0-84937515439
- Other Identifier
- 991019167740504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Physiology