Book chapter
Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area
Pharmacological Intervention in the Aging Process
1978
PMID: 645471
Abstract
Systemic treatment with the catecholamine precursor 1-dopa has been shown to reinstate ovarian cycles in the aged female rat (Quadri et al., 1973; Linnoila and Cooper, 1976). In an effort to determine if this effect is mediated via the action of 1-dopa on CNS catecholamines, we observed ovarian function after placing small amounts of 1-dopa directly into selected brain regions of aged rats (14 to 22 months old) bearing chronically implanted cannulae. Ovarian cycles could be reliably reinstated when 1-dopa was placed in the medial preoptic area of constant estrus or recurrently pseudopregnant females. This treatment was more effective (i.e. greater proportion of females responding.) and of longer duration (i.e. greater number of cycles observed) in 14–16 month old females than in the 22 month old females. Placement of 1-dopa in the septum, hippocampus or cortex had no effect on ovarian function. Placement of the norepinephrine precursor dlthreo-dihydroxyphenylserine (DOPS) or the neutral amino acid leucine in the four brain regions was without effect on ovarian function. The results will be discussed in terms of possible regional changes in brain amines with age.
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Details
- Title
- Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area
- Creators
- Ralph L. Cooper - Duke Medical CenterSteven Brandt - Duke Medical CenterMarkku Linnoila - Duke Medical CenterLouise H. Greenberg - Drexel UniversityRobert K. Dix - Drexel UniversityBenjamin Weiss - Drexel UniversityK. Reichlmeier - SandenA. Enz - SandenP. Iwangoff - SandenW. Meier-Ruge - SandenL. R. Weiss - Food and Drug AdministrationS. Krop - Food and Drug AdministrationBryon N. de Sousa - Drexel UniversityZ. V. Kendrick - Drexel UniversityJay Roberts - Drexel UniversitySteven I. Baskin - Drexel UniversityThomas L. Klug - Temple UniversityRichard C. Adelman - Temple UniversityC. Lee RobinetteMichael G. Mawhinney - University Medical CenterCynthia J. Moore - Temple CollegeArthur G. Schwartz - Temple CollegeR. N. Sorrentino - Syracuse UniversityJ. R. Florini - Syracuse UniversityD. D. Schocken - Baltimore City Health DepartmentG. S. Roth - Baltimore City Health DepartmentP. J. Gill - United States Department of Veterans AffairsD. M. Hanson - United States Department of Veterans AffairsA. Y. Sun - University of MissouriG. Y. Sun - University of MissouriWalter X. Balcavage - Indiana State UniversityDouglas Bell - Indiana UniversityVincent J. Cristofalo - Indiana UniversityTorsten Alväger - Indiana State UniversityJames J. Leyden - University of PennsylvaniaKenneth J. McGinley - University of PennsylvaniaGary L. Grove - University of PennsylvaniaAlbert M. Kligman - University of PennsylvaniaPhillip I. Good - W.E. Upjohn Institute for Employment ResearchN. I. Swislocki - Memorial Sloan Kettering Cancer CenterJ. Tierney - Memorial Sloan Kettering Cancer CenterJ. Zinberg - Memorial Sloan Kettering Cancer CenterS. R. Pfeffer - Memorial Sloan Kettering Cancer CenterK. D. Munkres - University of Wisconsin SystemR. S. Rana - University of Wisconsin SystemEdward M. Cohen - Drexel UniversityPaula B. Goldberg - Drexel UniversitySallie-Ann Stoner - Drexel UniversityNancy E. Olashaw - The Wistar Institute
- Publication Details
- Pharmacological Intervention in the Aging Process
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US; Boston, MA
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-0017921785
- Other Identifier
- 991020836338304721