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Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area
Book chapter   Peer reviewed

Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area

Ralph L. Cooper, Steven Brandt, Markku Linnoila, Louise H. Greenberg, Robert K. Dix, Benjamin Weiss, K. Reichlmeier, A. Enz, P. Iwangoff, W. Meier-Ruge, …
Pharmacological Intervention in the Aging Process
1978
DOI: https://doi.org/10.1007/978-1-4684-7793-1_15
PMID: 645471

Abstract

Anterior Prostate Human Embryonic Lung Fibroblast Late Passage Cell Seminal Vesicle Ventral Prostate
Systemic treatment with the catecholamine precursor 1-dopa has been shown to reinstate ovarian cycles in the aged female rat (Quadri et al., 1973; Linnoila and Cooper, 1976). In an effort to determine if this effect is mediated via the action of 1-dopa on CNS catecholamines, we observed ovarian function after placing small amounts of 1-dopa directly into selected brain regions of aged rats (14 to 22 months old) bearing chronically implanted cannulae. Ovarian cycles could be reliably reinstated when 1-dopa was placed in the medial preoptic area of constant estrus or recurrently pseudopregnant females. This treatment was more effective (i.e. greater proportion of females responding.) and of longer duration (i.e. greater number of cycles observed) in 14–16 month old females than in the 22 month old females. Placement of 1-dopa in the septum, hippocampus or cortex had no effect on ovarian function. Placement of the norepinephrine precursor dlthreo-dihydroxyphenylserine (DOPS) or the neutral amino acid leucine in the four brain regions was without effect on ovarian function. The results will be discussed in terms of possible regional changes in brain amines with age.

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