Book chapter
Spinal Cord Stimulation: Effect on Motor Function in Parkinson’s Disease
Handbook of Spine Technology, pp 473-481
01 Jan 2021
Abstract
Invasive high frequency electrical stimulation of the brain, deep brain stimulation (DBS), has become a standard of care intervention for improving motor symptoms in Parkinson’s disease (PD). Although DBS has been shown to improve many of the cardinal motor symptoms of PD including dyskinesias, bradykinesia, tremor, and rigidity, DBS has not shown consistent benefit for gait dysfunction in PD. Spinal cord stimulation (SCS) is an older form of electrical neuromodulation and has been used in humans for decades to treat primarily chronic pain disorders. Over the past decade, there has been a growing numbers of animal and human studies suggesting that SCS may improve motor symptoms, especially gait dysfunction problems such as freezing, in patients with PD. SCS has no current regulatory approval for usage in PD motor symptomatology and many of the benefits of SCS in PD patient have been incidentally observed in PD patients who were implanted with SCS for chronic pain. This chapter will review the published evidence for SCS in PD and discuss possible mechanisms for motor improvement in PD in addition to pain alleviation.
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Details
- Title
- Spinal Cord Stimulation: Effect on Motor Function in Parkinson’s Disease
- Creators
- Nestor D. TomyczTimothy LeichliterSaadyah AverickBoyle C. ChengDonald M. WhitingBoyle C. Cheng
- Publication Details
- Handbook of Spine Technology, pp 473-481
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- SOM Dean - Research Administration; Surgery; Neurosurgery
- Scopus ID
- 2-s2.0-85150543164
- Other Identifier
- 991021463578004721