Book chapter
Substrate Elasticity as a Probe to Measure Mechanosensing at Cell-Cell and Cell-Matrix Junctions
Mechanobiology of Cell-Cell and Cell-Matrix Interactions
21 Jan 2011
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In vivo, most cells are mechanically and chemically connected to other cells or to a variety of polymeric networks generically called the extracellular matrix (ECM). Adhesive contacts are formed by distinct classes of transmembrane protein complexes that have specific binding sites for extracellular targets on one side of the membrane and cytoplasmic domains that engage specific elements of the cytoskeleton and signal transduction systems. Engagement of cell-cell or cell-matrix contact both initiates and depends on mechanical signaling from inside and outside the cell, but also depends on the forces generated at the cell-cell or cell-ECM junction. This chapter will summarize some recent studies of mechanotransduction at cell adhesion sites and present examples of the interplay between cell-cell or cell-matrix contacts in fibroblasts, endothelial cells, cardiac myocytes, T lymphocytes and other cell types.
Metrics
Details
- Title
- Substrate Elasticity as a Probe to Measure Mechanosensing at Cell-Cell and Cell-Matrix Junctions
- Creators
- Jessamine P. WinerAnant ChopraJ. Yasha KreshPaul A. Janmey - University of Pennsylvania
- Publication Details
- Mechanobiology of Cell-Cell and Cell-Matrix Interactions
- Publisher
- Springer US; Boston, MA
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000288933000002
- Scopus ID
- 2-s2.0-84894066871
- Other Identifier
- 991019168684704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Cell Biology