Book chapter
THEORETICAL ASSESSMENT OF A VALIDATION TECHNIQUE FOR NONLINEAR PHYSIOLOGICAL MODELS
Proceedings of the Sixth New England Bioengineering Conference, pp 395-398
1978
Abstract
This chapter presents theoretical assessment of a validation technique for nonlinear physiological models. These models were validated by comparing data obtained from the model with in-vivo data using time domain and frequency domain techniques to analyze the observed hemodynamic waveforms. These measures of validity imply that the most desirable model is that which best reproduces the waveforms observed in-vivo. To quantify the ability of the model to follow trends exhibited by the natural system, a state of the model that corresponds to a state of the natural system is specified. The state is defined by the hemodynamic parameters of interest, such as mean pressures, cardiac output, peak pressures, etc. The difference or the distance between the state of the model and the state of the natural system is defined as a metric. With the exception of the effect on cardiac output, the least sensitive parametric variat on in the model is occlusion of branch vessels.
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Details
- Title
- THEORETICAL ASSESSMENT OF A VALIDATION TECHNIQUE FOR NONLINEAR PHYSIOLOGICAL MODELS
- Creators
- William J. Ohley - University of Rhode IslandWalter S. Kuklinski - University of Rhode IslandDov Jaron - University of Rhode Island
- Publication Details
- Proceedings of the Sixth New England Bioengineering Conference, pp 395-398
- Publisher
- Elsevier
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]; Drexel University
- Other Identifier
- 991019341957604721