Book chapter
Targeting the ErbB Family in Head and Neck Cancer
Molecular Determinants of Head and Neck Cancer
01 Jan 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Members of the ErbB receptor tyrosine kinase family (EGFR, HER2, HER3, and HER4), which regulate cell differentiation, proliferation, and survival, are commonly overexpressed and hyperactivated in squamous cell carcinoma of the head and neck (SCCHN). This abnormal expression and activity triggers multiple effector cascades that promote cancer growth, involving signaling through Ras-Raf-ERK1/2, PI3K/AKT/mTOR, JAK1/STAT3, PLC/PKC, and others. Targeting of EGFR remains one of the most common therapies for patients with SCCHN, with newer therapies also targeting additional ErbB family members and ErbB effectors, and exploring combinatorial approaches. In this chapter, we will describe the biology of ErbB family receptors in normal cells and in SCCHN, current and novel therapeutic approaches, and mechanisms underlying resistance to anti-EGFR therapy.
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Details
- Title
- Targeting the ErbB Family in Head and Neck Cancer
- Creators
- Anna Kiseleva - Fox Chase Cancer CenterTim N. Beck - Fox Chase Cancer CenterIlya G. Serebriiskii - Fox Chase Cancer CenterHanqing Liu - Jiangsu UniversityBarbara Burtness - Yale UniversityErica A. Golemis - Fox Chase Cancer Center
- Contributors
- B Burtness (Editor) - Yale UniversityE A Golemis (Editor) - Fox Chase Cancer Center
- Publication Details
- Molecular Determinants of Head and Neck Cancer
- Series
- Current Cancer Research
- Publisher
- Springer Nature; CHAM
- Number of pages
- 55
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000481824000002
- Scopus ID
- 2-s2.0-85111878286
- Other Identifier
- 991019319080304721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Oncology