Book chapter
Taurine in 24-h Urine Samples Is Inversely Related to Cardiovascular Risks of Middle Aged Subjects in 50 Populations of the World
Taurine 9, pp 623-636
2015
PMID: 25833532
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We previously showed that 24-h urinary taurine (Tau) excretion was inversely associated with mortality due to coronary heart diseases (CHD) and stroke. The aim of this study was to examine the association between 24-h urinary Tau/creatinine (Cre) ratio and cardiovascular disease risk factors, including body mass index (BMI), blood pressure (BP), serum total cholesterol (TC) and prevalence of obesity, hypertension and hypercholesterolemia.
A cross sectional analysis was conducted among 4,211 participants (2,120 men and 2,091 women) aged 48–56 from 50 population samples of 22 countries in the World Health Organization-coordinated Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study (1985–1994).
According to linear regression analyses adjusted for traditional risk factors such as age, sex and anti-hypertensive treatment, Tau/Cre was inversely associated with BMI, systolic BP, diastolic BP and TC (P for linear trend <0.001, respectively). These associations were not markedly altered by further adjustment for 24-h urinary sodium/Cre, potassium/Cre, calcium/Cre, magnesium/Cre and cohort effects. After adjusting for the traditional risk factors, the prevalence of obesity, hypertension and hypercholesterolemia among the subjects within the lowest quintile of the Tau/Cre ratio was 2.84 (95 % CI: 2.04, 3.96; P for trend <0.001), 1.22 (95 % CI: 0.98, 1.51; P < 0.05) and 2.20 (95 % CI: 1.73, 2.80; P < 0.001) times higher than that in the subjects within the highest quintile. These associations were not appreciably altered by further adjustment for other 24-h urinary markers and cohort effects.
In conclusion, higher Tau/Cre was associated with lower cardiovascular disease risk factors, including BMI, BP, TC, obesity, hypertension and hypercholesterolemia.
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Details
- Title
- Taurine in 24-h Urine Samples Is Inversely Related to Cardiovascular Risks of Middle Aged Subjects in 50 Populations of the World
- Creators
- Miki Sagara - Department of Preventive Nutritional Medicine, Research Institute for Production Development, International (Former WHO-Collaborating) Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, JapanShigeru Murakami - Department of Bioscience, Fukui Prefectural University, Fukui, JapanShunsaku Mizushima - Department of Epidemiology and Public Health, Yokohama City University Graduate School of Medicine, Yokohama, JapanLongjian Liu - Department of Epidemiology & Biostatistics, Drexel University School of Public Health, Pennsylvania, USAMari Mori - Institute for World Health Development, Mukogawa Women’s University, Nishinomiya, JapanKatsumi Ikeda - School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, JapanYasuo Nara - Department of Preventive Nutritional Medicine, Research Institute for Production Development, International (Former WHO-Collaborating) Center for Research on Primary Prevention of Cardiovascular Diseases, Kyoto, JapanYukio Yamori - Institute for World Health Development, Mukogawa Women’s University, Nishinomiya, Japan
- Publication Details
- Taurine 9, pp 623-636
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000363250200051
- Scopus ID
- 2-s2.0-84926670167
- Other Identifier
- 991014878250404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Medicine, Research & Experimental