Book chapter
The Future of Altered Fractionation
Alternate Fractionation in Radiotherapy, pp 41-63
2018
Abstract
Radiotherapy remains at the core of treatment for a number of disease sites, especially breast, prostate, and lung cancers, the three most commonly diagnosed cancers in 2015 (Siegel et al. 2016). Radiotherapy (RT) has typically been delivered in multifraction regimens dating back to radiobiology experiments in the 1920s and 1930s which demonstrated that dividing the radiation dose into multiple treatments provides a balance between tumor control and normal tissue toxicity. Subsequent experimentation demonstrated that 1.8–2.0 Gy fractions of radiation delivered daily five times per week allows for repair of sublethal damage within normal tissues thereby reducing radiation toxicity while maximizing cell kill in most tumor types due to reassortment within radiosensitive phases of the cell cycle and reoxygenation of tissues (Hall and Giaccia 2012).
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Details
- Title
- The Future of Altered Fractionation
- Creators
- Brian J. Gebhardt - UPMC Hillman Cancer CenterZachary D. Horne - UPMC Hillman Cancer CenterSushil Beriwal - UPMC Hillman Cancer Center
- Contributors
- Mark Trombetta (Editor)Jean-Philippe Pignol (Editor)Paolo Montemaggi (Editor)Luther W. Brady (Editor)
- Publication Details
- Alternate Fractionation in Radiotherapy, pp 41-63
- Series
- Medical Radiology
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Scopus ID
- 2-s2.0-85054342109
- Other Identifier
- 991021897281104721