Book chapter
The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials
Biomaterials in Regenerative Medicine and the Immune System, pp 17-34
05 Sep 2015
Abstract
Biomaterials are part of the solution to many unmet clinical needs, from implantable sensors to drug delivery devices and engineered tissues. However, biomaterials face an inflammatory environment upon implantation, representing a potential obstacle to their success. In this chapter, we review the consequences of the foreign body response (FBR) for biomaterial function and strategies that have been used to inhibit the FBR. We focus on the role of the macrophage, the cell at the center of the inflammatory response, and discuss implications of changing macrophage behavior on biomaterial acceptance or rejection. Finally, we discuss recent discoveries in the role of macrophage phenotype, ranging from pro-inflammatory (M1) to anti-inflammatory (M2), and the role it plays in wound healing and biomaterial vascularization. We conclude with a discussion of biomaterial design strategies that have been suggested to positively interact with and potentially control macrophages in order to improve interactions with the inflammatory response.
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36 citations in Scopus
Details
- Title
- The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials
- Creators
- Tony Yu - Drexel UniversityValerie J. Tutwiler - Drexel UniversityKara Spiller - Drexel University
- Publication Details
- Biomaterials in Regenerative Medicine and the Immune System, pp 17-34
- Publisher
- Springer International Publishing; Cham
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Scopus ID
- 2-s2.0-84955402842
- Other Identifier
- 991019173746004721