Book chapter
The Senescence Arrest Program and the Cell Cycle
Cell Cycle Control
01 Jan 2014
PMID: 24906313
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
All living organisms are subject to progressive loss of function and damage to their tissues, a process known as aging. At the cellular level, the accumulation of damage to DNA, proteins, and organelles induces cellular senescence, a stress-response pathway that likely influences the aging process. Although the senescence arrest program was initially described in vitro, accumulating evidence suggests that this damage response program occurs in a variety of pathologic settings. This review discusses aspects of the senescence program, their interrelationships with damage arrest pathways, the cell cycle, and the impact of senescence in vivo.
Metrics
Details
- Title
- The Senescence Arrest Program and the Cell Cycle
- Creators
- Alessandro Bitto - University of WashingtonElizabeth P. Crowe - Drexel UniversityChad Lerner - University of Rochester Medical CenterClaudio Torres - Drexel UniversityChristian Sell - Drexel University
- Contributors
- E Noguchi (Editor)M C Gadaleta (Editor)
- Publication Details
- Cell Cycle Control
- Series
- Methods in Molecular Biology
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 10
- Grant note
- AG039799 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R21AG039799 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000338508500009
- Scopus ID
- 2-s2.0-84922480593
- Other Identifier
- 991019169625004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology