Book chapter
Transforming Growth Factor Beta (TGF-beta) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)
Molecular Determinants of Head and Neck Cancer
01 Jan 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transforming growth factor receptor beta (TGF-beta) signaling is commonly dysregulated in head and neck squamous cell carcinoma (HNSCC). TGF-beta signaling influences homeostasis in normal epithelial cells and regulates a critical signaling network during development. In HNSCC, TGF-beta signaling frequently promotes cell invasion, metastasis, proliferation, and drug resistance and may present an important therapeutic target. Canonical TGF-beta signaling generally involves activation of SMAD effector proteins, most prominently SMAD2 and SMAD3, whereas noncanonical TGF-beta signaling requires signal propagators including ERK, AKT, and RAF, also commonly employed by receptor tyrosine kinases (RTKs), thereby providing opportunities for signaling crosstalk. Several members of the TGF-beta superfamily are being explored as potential targets to control drug resistance and metastatic spread, both important barriers to cure in HNSCC. In this chapter, the roles of TGF-beta in HNSCC are described, with particular focus on molecular signaling, TGF-beta's role in controlling gene expression, and relevant therapeutic directions involving TGF-beta.
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Details
- Title
- Transforming Growth Factor Beta (TGF-beta) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)
- Creators
- Alexander E. Kudinov - Fox Chase Cancer CenterTim N. Beck - Fox Chase Cancer Center
- Contributors
- B Burtness (Editor)E A Golemis (Editor)
- Publication Details
- Molecular Determinants of Head and Neck Cancer
- Series
- Current Cancer Research
- Publisher
- Springer Nature; CHAM
- Number of pages
- 27
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000481824000004
- Scopus ID
- 2-s2.0-85111872554
- Other Identifier
- 991019319089604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Oncology