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Translation of Pro-Angiogenic and Anti-Angiogenic Therapies into Clinical Use
Book chapter

Translation of Pro-Angiogenic and Anti-Angiogenic Therapies into Clinical Use

Sujata K. Bhatia
Mechanical and Chemical Signaling in Angiogenesis, pp 261-278
2013
DOI: https://doi.org/10.1007/978-3-642-30856-7_13

Abstract

Interferon Alfa Metastatic Renal Cell Carcinoma Receptor Tyrosine Kinase Inhibitor Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor
Angiogenesis is a central physiological process that establishes blood supply and oxygen supply to tissues, thereby enabling the growth and maintenance of nascent bodily structures. Angiogenic signals function throughout the lifecycle to ensure perfusion, proliferation, and preservation of cells, tissues, and organs. During embryonic development, angiogenesis is absolutely critical; the generation of blood vessels is crucial to the formation of every organ. In adulthood, angiogenesis is necessary for wound healing, as well as recovery from ischemic insults; in such cases, it is beneficial to promote angiogenesis. However, angiogenesis is undesirable and pathological in the context of cancerous tumors, as well as diabetic retinopathy; in these cases, it is preferable to halt angiogenesis. Thus, pro-angiogenic and anti-angiogenic signals must operate in balance to assure physiological health. This chapter reviews current knowledge regarding biochemical regulators of angiogenesis, and highlights molecular targets of pro-angiogenic and anti-angiogenic therapies. The chapter additionally discusses current progress in translating both pro-angiogenic and anti-angiogenic therapeutics into clinical usage, and identifies potential barriers to the clinical introduction of such therapeutics. Finally, the chapter suggests future basic research and clinical research priorities for tailoring angiogenesis to address patient needs.

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