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Use of 5-Fluorouracil in the Treatment of Dysphonia
Book chapter

Use of 5-Fluorouracil in the Treatment of Dysphonia

Robert T. Sataloff, Lily Stevenson and Ramon A. Franco
Office-Based Surgical Procedures in Otolaryngology, pp 249-252
2027
DOI: https://doi.org/10.1016/B978-0-443-10617-0.00042-3
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Abstract

5-Fluorouracil Dexamethasone Laryngology Outpatient procedures Vocal fold scar Voice Handicap Index-10 (VHI-10)
The use of 5-fluorouracil (5-FU) in addition to Dexamethasone should be considered for the treatment of vocal fold scar. Dysphonia as a result of vocal fold scar is caused by loss of mucosal pliability and inability to modulate normally the airflow that produces the glottic source signal. An individual with a vocal fold scar often must increase effort (high phonation threshold pressure) to overcome the stiffness, which leads to a strained voice and compensatory hyperfunction that may further damage the vocal folds. In general, once the vibratory margin of the vocal fold has been scarred, it has not been possible to return vocal fold function to normal, but often it can be improved. Although vocal fold scar has been studied, there is no universally successful treatment. The application of 5-FU for treating vocal fold scars was introduced by the author (Robert Sataloff) in 2018. Results demonstrate clinical benefit, represented on the VHI-10 and observed postoperative mucosal wave.

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