Book chapter
Use of the Quartz Crystal Microbalance with Dissipation Monitoring for Pharmacological Evaluation of Cell Signaling Pathways Mediated by Epidermal Growth Factor Receptors
Label-Free Biosensor Methods in Drug Discovery
2015
Abstract
The quartz crystal microbalance with dissipation monitoring (QCM-D) is a highly sensitive, noninvasive, and label-free sensing device. This device is capable of providing real-time monitoring of the properties of complex biological systems, such as cells, in response to environmental stimuli. The unique dissipation monitoring function of the QCM-D has been shown to be able to profile the inhibition of signaling pathways mediated by epidermal growth factor receptors. The QCM-D method has the potential to become an effective sensing platform for drug screening.
Metrics
11 Record Views
1 citations in Scopus
Details
- Title
- Use of the Quartz Crystal Microbalance with Dissipation Monitoring for Pharmacological Evaluation of Cell Signaling Pathways Mediated by Epidermal Growth Factor Receptors
- Creators
- Jennifer Y. Chen - Drexel UniversityMarcela P. Garcia - Drexel UniversityLynn S. Penn - Drexel UniversityJun Xi - Drexel University
- Publication Details
- Label-Free Biosensor Methods in Drug Discovery
- Series
- Methods in Pharmacology and Toxicology
- Publisher
- Springer New York; New York, NY
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Chemistry
- Scopus ID
- 2-s2.0-84958608391
- Other Identifier
- 991019173517704721