Book chapter
Using the Core and Supra Genomes to Determine Diversity and Natural Proclivities among Bacterial Strains
Caister Academic Press
01 Jan 2014
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The realization at the beginning of the current millennium that there are very substantial differences in gene content among the component strains of bacterial species, together with the observation that there exists profound phenotypic heterogeneity amongst these strains, led directly to the development of the field of comparative bacterial genomics, and the concepts of the core and supra (pan) genomes. The core genome is composed of the set of genes shared by all members of a given species (or other taxonomic grouping), and the supragenome is the set of all genes contained by the same grouping. Those genes not present in the core genome, but present in the supragenome, are referred to as distributed (accessory) genes, and it is this last group that is responsible for much of the intraspecies heterogeneity. In the current work we provide comparative genomic evidence for both the core genome hypothesis and the distributed genome hypothesis, and describe a testable means to determine if a strain or particular group of strains belongs within an extant genomically defined species (or other taxonomic) grouping.
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Details
- Title
- Using the Core and Supra Genomes to Determine Diversity and Natural Proclivities among Bacterial Strains
- Creators
- Laura Nistico - Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USAJosh Earl - Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USALuisa Hiller - Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USAAzad Ahmed - Allegheny-Singer Research InstituteAdam Retchless - Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USABenjamin Janto - Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USAJ. William Costerton - Allegheny Gen Hosp, Dept Orthopaed Surg, Pittsburgh, PA 15212 USAFen Z. Hu - Drexel Univ, Coll Med, Dept Microbiol & Immunol, Pittsburgh, PA USAGarth D. Ehrlich - Drexel University
- Contributors
- T L Skovhus (Editor)S M Caffrey (Editor)CRJ Hubert (Editor)
- Publisher
- Caister Academic Press; WYMONDHAM
- Number of pages
- 16
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170474604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Microbiology