Book chapter
c-MET in Head and Neck Squamous Cell Carcinoma
Molecular Determinants of Head and Neck Cancer
01 Jan 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The kinase receptor c-MET (MET proto-oncogene, receptor tyrosine kinase; also known as the hepatocyte growth factor receptor) and its ligand hepatocyte growth factor/scatter factor (HGF/SF) are two promising, potentially therapeutically exploitable targets in head and neck squamous cell carcinoma (HNSCC). c-MET is commonly overexpressed in head and neck cancer cells compared to normal epithelial cells and HGF/SF is often detected at high expression levels in tumor-adjacent mesenchymal cells, inducing paracrine activation of c-MET to support tumor growth and proliferation. Blocking this paracrine activity has been shown to reduce the proliferative capacity of HNSCC cells. Importantly, c-MET signaling outputs intersect with those of multiple other signaling pathways that drive or otherwise contribute to HNSCC cell survival and spread, including EGFR, HER2, SRC, STAT3, PI3K, RAS, GRB2, and others. In this review, we emphasize the roles of c-MET and HGF in HNSCC as well as the potential for therapeutic targeting of this signaling axis.
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Details
- Title
- c-MET in Head and Neck Squamous Cell Carcinoma
- Creators
- John Kaczmar - Medical University of South CarolinaTim N. Beck - Drexel University
- Contributors
- B Burtness (Editor)E A Golemis (Editor)
- Publication Details
- Molecular Determinants of Head and Neck Cancer
- Series
- Current Cancer Research
- Publisher
- Springer Nature; CHAM
- Number of pages
- 26
- Resource Type
- Book chapter
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000481824000003
- Scopus ID
- 2-s2.0-85111846674
- Other Identifier
- 991019319093104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Oncology