Review
Designer channels: site-directed mutagenesis as a probe for structural features of channels and receptors
Trends in Neurosciences, v 8(8), pp 364-368
1985
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Abstract
Site-directed mutagenesis is a powerful technique for determining structure—function relations in proteins. The problems addressed can range from the role of glycosylation of a single amino acid in receptor-channel complex assembly to the mechanism of ion selectivity in the Na
+ channel. As the questions become more complicated, it is unlikely that a single amino acid substitution can provide sufficient information; rather, a series of mutations will be required. As more becomes known about the relevant structural features of individual ion channels and receptors, general principles may emerge which will aid in understanding how other, less well-known, channels work.
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Details
- Title
- Designer channels: site-directed mutagenesis as a probe for structural features of channels and receptors
- Creators
- Michael M. White - California Institute of Technology
- Publication Details
- Trends in Neurosciences, v 8(8), pp 364-368
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1985APZ5900009
- Scopus ID
- 2-s2.0-0021933392
- Other Identifier
- 991020837743504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences