Review
Effects of age on the adrenergic cardiac neuroeffector junction
Life Sciences, v 35(26), pp 2585-2591
1984
PMID: 6513728
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although it is clear that adrenergic nervous system control of cardiac function decreases with age and that the effector organ fails to adjust to this decreased control, it is not completely evident which of the many mechanisms operant at the adrenergic-cardiac neuroeffector junction contribute to this state. Prejunctionally, it appears that norepinephrine content decreases with age and that adrenergic axonal degeneration occurs. Also, evidence is available to suggest that modulation by prejunctional alpha adrenergic receptors of norepinephrine release is altered with increasing age, as is neuronal uptake of norepinephrine. Postjunctionally, it appears that beta-adrenergic receptor sensitivity to agonists undergoes age-related alterations, and possibly post receptor mechanisms involved in receptor-response coupling. Other mechanisms, such as those involved in transmitter uptake into extraneuronal sites, adrenergic neuronal responsiveness to stimulation, transmitter release and turnover, calcium and prejunctional receptor modulation of transmitter release, postjunctional receptor development of supersensitivity or subsensitivity, need further elucidation in order to have an understanding of the factors that contribute to the breakdown of homeostatic mechanisms that regulate the heart.
Metrics
Details
- Title
- Effects of age on the adrenergic cardiac neuroeffector junction
- Creators
- Paula Bursztyn Goldberg - Drexel UniversityMargaret S. Kreider - Drexel UniversityJay Roberts - Drexel UniversityJames R Roberts - Emergency Medicine
- Publication Details
- Life Sciences, v 35(26), pp 2585-2591
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1984TU16300001
- Scopus ID
- 2-s2.0-0021739641
- Other Identifier
- 991019184083304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy