Review
Effects of corticotropin releasing hormone on appetitive behaviors
Peptides, v 13(3), pp 609-621
01 May 1992
PMID: 1523173
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Corticotropin releasing hormone (CRH) is a 41-residue hypothalamic neuropeptide that has been shown to have potent behavioral effects in animals and has been implicated in clinical disorders in man. This review focuses on those aspects of the behavioral effects of CRH related to food-associated behaviors. The effects of CRH on food intake are compared with its effects on performances maintained by food presentation, and contrasted with the effects of CRH on performances maintained by other events. The effects of CRH antagonists and drugs that interact with the behavioral effects of CRH are also reviewed, particularly with respect to their direct effects on food intake. Lastly, data assessing the effects of CRH administration on central neurotransmitter levels are presented and compared with levels seen in clinical populations. The effect of CRH on food intake seen in animals is consistent with a putative role for CRH in clinical syndromes where appetite suppression is apparent. Since some of the effects of CRH on food intake are subject to pharmacological intervention, strategies directed at peptidergic mechanisms of psychiatric disorders should be explored.
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Details
- Title
- Effects of corticotropin releasing hormone on appetitive behaviors
- Creators
- John R. Glowa - National Institute of Mental HealthJames E. Barrett - Eli Lilly (United States)Jonetta Russell - National Institute of Mental HealthPhil W. Gold - National Institute of Mental Health
- Publication Details
- Peptides, v 13(3), pp 609-621
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:A1992JB24800029
- Scopus ID
- 2-s2.0-0026651070
- Other Identifier
- 991020836512404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy