Review
Genetic Approaches to Neurotrauma Research: Opportunities and Potential Pitfalls of Murine Models
Experimental Neurology, v 157(1)
May 1999
PMID: 10222106
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Genetic strategies provide new ways to define the molecular cascades that regulate the responses of the mammalian nervous system to injury. Genetic interventions also provide opportunities to manipulate and control key molecular steps in these cascades, so as to modify the outcome of CNS injury. Most current genetic strategies involve the use of mice, an animal that has not heretofore been used extensively for neurotrauma research. Therefore, one purpose of the present review is to consider how mice respond to neural trauma, focusing especially on recent information that reveals important differences between mice and rats, and between different inbred strains of mice. The second aim of this review is to provide a brief introduction to the opportunities, caveats, and potential pitfalls of studies that use genetically modified animals for neurotrauma research.
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Details
- Title
- Genetic Approaches to Neurotrauma Research: Opportunities and Potential Pitfalls of Murine Models
- Creators
- Oswald Steward - University of VirginiaP.Elyse Schauwecker - University of VirginiaLloyd Guth - University of VirginiaZiyin Zhang - University of VirginiaMinoru Fujiki - University of VirginiaDenise Inman - University of VirginiaJean Wrathall - Georgetown University Medical CenterGerd Kempermann - Laboratory of Genetics, The Salk Institute, La Jolla, California, 92037Fred H. Gage - Salk Institute for Biological StudiesKathryn E. Saatman - University of PennsylvaniaRamesh Raghupathi - University of PennsylvaniaTracy McIntosh - University of Pennsylvania
- Publication Details
- Experimental Neurology, v 157(1)
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000080226100002
- Scopus ID
- 2-s2.0-0032933945
- Other Identifier
- 991019222768404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences