Review
Hyperthermia following traumatic brain injury: a critical evaluation
Neurobiology of Disease, v 12(3), pp 163-173
2003
PMID: 12742737
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hyperthermia, frequently seen in patients following traumatic brain injury (TBI), may be due to posttraumatic cerebral inflammation, direct hypothalamic damage, or secondary infection resulting in fever. Regardless of the underlying cause, hyperthermia increases metabolic expenditure, glutamate release, and neutrophil activity to levels higher than those occurring in the normothermic brain-injured patient. This synergism may further compromise the injured brain, enhancing the vulnerability to secondary pathogenic events, thereby exacerbating neuronal damage. Although rigorous control of normal body temperature is the current standard of care for the brain-injured patient, patient management strategies currently available are often suboptimal and may be contraindicated. This article represents a compendium of published work regarding the state of knowledge of the relationship between hyperthermia and TBI, as well as a critical examination of current management strategies.
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Details
- Title
- Hyperthermia following traumatic brain injury: a critical evaluation
- Creators
- Hilaire J Thompson - School of Nursing, The University of Pennsylvania, Philadelphia, PA 19104-6020, USANancy C Tkacs - School of Nursing, The University of Pennsylvania, Philadelphia, PA 19104-6020, USAKathryn E Saatman - Head Injury Center, Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA 19104-6316, USARamesh Raghupathi - Head Injury Center, Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA 19104-6316, USATracy K McIntosh - Head Injury Center, Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA 19104-6316, USA
- Publication Details
- Neurobiology of Disease, v 12(3), pp 163-173
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000182949100001
- Scopus ID
- 2-s2.0-0038756021
- Other Identifier
- 991014877908204721
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- Web of Science research areas
- Neurosciences