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Review
IL-1β in Neoplastic Disease and the Role of Its Tumor-Derived Form in the Progression and Treatment of Metastatic Prostate Cancer
Cancers, v 17(2), 290
17 Jan 2025
PMID: 39858071
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Since its discovery, IL-1β has taken center stage as a key mediator of a very broad spectrum of diseases revolving around immuno-mediated and inflammatory events. Predictably, the pleiotropic nature of this cytokine in human pathology has led to the development of targeted therapeutics with multiple treatment indications in the clinic. Following the accumulated findings of IL-1β’s central modulatory role in the immune system and the implication of inflammatory pathways in cancer, the use of IL-1β antagonists was first proposed and then also pursued for oncology disorders. However, this approach has consistently relied on the perceived need of interfering with IL-1β synthesized and secreted by immune cells. Herein, we discuss the importance of IL-1β derived from cancer cells which impacts primary tumors, particularly metastatic lesions, separately from and in addition to its more recognized role in immune-mediated inflammatory events. To this end, we focus on the instrumental contribution of IL-1β in the establishment and progression of advanced prostate adenocarcinoma. Special emphasis is placed on the potential role that the standard-of-care treatment strategies for prostate cancer patients have in unleashing IL-1β expression and production at metastatic sites. We conclude by reviewing the therapeutics currently used for blocking IL-1β signaling and propose a rationale for their concomitant use with standard-of-care treatments to improve the clinical outcomes of advanced prostate cancer.
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Details
- Title
- IL-1β in Neoplastic Disease and the Role of Its Tumor-Derived Form in the Progression and Treatment of Metastatic Prostate Cancer
- Creators
- Yetunde Ebunlomo Oyende - Drexel University, College of MedicineLuke Taus - Drexel UniversityAlessandro Fatatis (Corresponding Author) - Drexel University, Pharmacology and Physiology
- Publication Details
- Cancers, v 17(2), 290
- Publisher
- MDPI
- Number of pages
- 25
- Grant note
- NCI: R01CA259358
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001403699900001
- Scopus ID
- 2-s2.0-85215755871
- Other Identifier
- 991022019119804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology