Review
Mechanisms by which Thiazolidinediones Enhance Insulin Action
Trends in Endocrinology & Metabolism, v 10(1)
1999
PMID: 10322388
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Thiazolidinediones (TZDs) are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabetes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor, peroxisome proliferator-activated receptor γ (PPARγ). PPARγ is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potential explanations for this paradox are discussed in this review.
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Details
- Title
- Mechanisms by which Thiazolidinediones Enhance Insulin Action
- Creators
- Mauricio J Reginato - University of PennsylvaniaMitchell A Lazar - University of Pennsylvania
- Publication Details
- Trends in Endocrinology & Metabolism, v 10(1)
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000081329700001
- Scopus ID
- 2-s2.0-0033039662
- Other Identifier
- 991020100201304721
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- Web of Science research areas
- Endocrinology & Metabolism