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Review
Pharmaceutical considerations in treating neuropathic pain in athletes
International orthopaedics
12 Feb 2025
PMID: 39937238
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Neuropathic pain is a complex and challenging condition that arises from abnormal processing of somatosensory information, often following nerve injury or dysfunction. Its diagnosis involves a detailed clinical history, sensory examination, and diagnostic tests such as electromyography, nerve conduction studies, and MRI to identify nerve damage or structural causes. In athletes, neuropathic pain can result from nerve entrapment syndromes, post-surgical complications, or peripheral nerve injuries, with unique challenges in pain assessment due to psychological factors and exercise-induced changes. Pharmacological management primarily includes anticonvulsants (e.g., gabapentin, pregabalin) and antidepressants (e.g., tricyclics, SNRIs), tailored to minimize side effects that could impair athletic performance. Effective treatment requires a careful balance to manage pain while maintaining physical capabilities. When treating athletes for neuropathic pain, healthcare providers must ensure prescribed medications comply with World Anti-Doping Agency (WADA) regulations. Narcotics (opioids) and cannabinoids are prohibited in-competition. Glucocorticoids are also banned in-competition if administered via injection, orally, or rectally, and elevated levels in urine may lead to sanctions.
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Details
- Title
- Pharmaceutical considerations in treating neuropathic pain in athletes
- Creators
- Asif M Ilyas - Drexel University, PediatricsSina Ramtin (Corresponding Author) - Rothman Institute
- Publication Details
- International orthopaedics
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:001418921800001
- Scopus ID
- 2-s2.0-85217801879
- Other Identifier
- 991022025836404721
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- Web of Science research areas
- Orthopedics