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Review
Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
Journal of Cancer, v 13(11), pp 3160-3176
01 Jan 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a stem-cell-like phenotype that is dictated by the expression of master regulator transcription factors, including OCT4, NANOG, and SOX2. These transcription factors are expressed via activation of multiple signaling pathways that drive cancer initiation and progression. Importantly, these same signaling pathways can be activated by select chemokine receptors. Chemokine receptors are increasingly being revealed as major drivers of the TIC phenotype, as their signaling can lead to activation of stemness-controlling transcription factors. Additionally, the cell surface expression of chemokine receptors provides a unique therapeutic target to disrupt signaling pathways that control the expression of master regulator transcription factors and the TIC phenotype. This review summarizes the master regulator transcription factors known to dictate the TIC phenotype, along with the complex signaling pathways that can mediate their expression and the chemokine receptors that are most upstream of this phenotype.
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Details
- Title
- Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
- Creators
- Anthony DiNataleMaria CastelliBradley NashOlimpia MeucciAlessandro Fatatis
- Publication Details
- Journal of Cancer, v 13(11), pp 3160-3176
- Publisher
- Ivyspring International Publisher Pty Ltd; Wyoming
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000922383400001
- Scopus ID
- 2-s2.0-85138637532
- Other Identifier
- 991019173446404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology