Review
Regulation of oxygen sensing in peripheral arterial chemoreceptors
International Journal of Biochemistry and Cell Biology, v 33(8), pp 755-774
2001
PMID: 11404180
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The carotid bodies are a small pair of highly vascularized and well perfused organs located at each carotid artery bifurcation, strategically situated to sense oxygen in arterial blood as it leaves the heart. Carotid body glomus cells are identified as the primary oxygen sensors, which respond to changes in blood
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within milliseconds. Acute hypoxia causes a rapid increase in carotid sinus nerve (CSN) activity, providing afferent signals to the respiratory center in the brainstem. Glomus cells secrete numerous neurotransmitters that modulate CSN firing rates. This review will discuss major hypotheses that have emerged regarding acute oxygen sensing by glomus cells. In contrast, chronic responses to hypoxia are much slower, involving cytosolic reactions that take place over several minutes and nuclear reactions which occur over several hours. Converging concepts from different areas of research in oxygen sensing cells and tissues (including the carotid body) have been combined to describe molecular and biochemical changes that take place in the carotid body with chronic hypoxia. These include oxygen dependent proteolytic processes in the cytosol and gene transcription in the nucleus. In addition, cellular and nuclear responses to chronic hypoxia will be discussed.
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Details
- Title
- Regulation of oxygen sensing in peripheral arterial chemoreceptors
- Creators
- Sukhamay Lahiri - University of PennsylvaniaCharmaine Rozanov - University of PennsylvaniaArijit Roy - University of PennsylvaniaBayard Storey - University of PennsylvaniaDonald G Buerk - University of Pennsylvania
- Publication Details
- International Journal of Biochemistry and Cell Biology, v 33(8), pp 755-774
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000170072700002
- Scopus ID
- 2-s2.0-0034981970
- Other Identifier
- 991019231643304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology