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Review
Strategies to Enhance Protein Delivery
Langmuir : the ACS journal of surfaces and colloids, v 41(10), pp 6457-6470
07 Mar 2025
PMID: 40052814
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Therapeutic proteins play a crucial role in modern healthcare. However, the rapid clearance of proteins in the circulation system poses a significant threat to their therapeutic efficacy. The generation of anti-drug antibodies expedites drug clearance, resulting in another challenge to overcome in protein delivery. Several methods to increase the circulation half-lives of these proteins and to minimize their immunogenicity have been developed. This Review discusses the causes of protein clearance in the body, evaluates the FDA-approved strategies to prolong protein circulation, and highlights recent progress in the field. Additionally, the strengths and drawbacks of these methods and our perspectives for advancing protein delivery are provided.
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Details
- Title
- Strategies to Enhance Protein Delivery
- Creators
- Yucheng Zhu - Drexel University, Materials Science and EngineeringWeisi Zhuang - Drexel University, Materials Science and EngineeringHao Cheng (Corresponding Author) - Drexel University, Materials Science and Engineering
- Publication Details
- Langmuir : the ACS journal of surfaces and colloids, v 41(10), pp 6457-6470
- Publisher
- ACS Publications
- Number of pages
- 14
- Grants
- Grant note
- National Institute of General Medical Sciences: R01GM155729 National Institute of General Medical Sciences of the National Institutes of Health: R56AI177800 National Institute of Allergy and Infectious Diseases of the National Institutes of Health
This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Grant R01GM155729 and by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Grant R56AI177800.
- Resource Type
- Review
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:001440302000001
- Scopus ID
- 2-s2.0-105001059937
- Other Identifier
- 991022032271504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary