Review
Targeting Diastolic Dysfunction by Genetic Engineering of Calcium Handling Proteins
Trends in Cardiovascular Medicine, v 13(2), pp 63-67
01 Feb 2003
PMID: 12586441
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diastolic heart failure (HF) is associated with significant morbidity and mortality, and is a growing medical problem in this country. Diastolic dysfunction is defined as an abnormality in myocardial relaxation that impairs filling during diastole and contributes to the clinical syndrome of HF. Effective clinical strategies to treat diastolic dysfunction are limited. This article focuses on the potential application of parvalbumin—a fast skeletal muscle calcium buffer—for remediation of slow relaxation in the failing heart.
Metrics
Details
- Title
- Targeting Diastolic Dysfunction by Genetic Engineering of Calcium Handling Proteins
- Creators
- Pierre Coutu - University of MichiganJennifer C Hirsch - University of MichiganMichael L Szatkowski - Einstein Medical Center PhiladelphiaJoseph M Metzger - University of Michigan
- Publication Details
- Trends in Cardiovascular Medicine, v 13(2), pp 63-67
- Publisher
- Elsevier
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000180950200004
- Scopus ID
- 2-s2.0-0037318398
- Other Identifier
- 991021838136004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems