Review
The combined immunological and anticociceptive defects of beige-J mice: The possible existence of A ‘μ-repressin’
Life Sciences, v 52(1), pp 1-8
1993
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A selective non-responsiveness to the analgesic effects of opiond μ receptor-, but not opiod δ receptor-, mediated antinociception in the tail-flick test has been identified in C57BL/6J-bj
J (beige-J) mice. The beige-J mutation is also known to give rise to multiple immunological disorders and immune cell dysfunctions. A link between these apparently disparate manifestations has been examined in a series of studies using, for example, adoptive transfer of spleen cells. The findings appear to have broad implications for the link between the immune and opioid systems.
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Details
- Title
- The combined immunological and anticociceptive defects of beige-J mice: The possible existence of A ‘μ-repressin’
- Creators
- Robert B. Raffa - Nashotah House Theological SeminaryJoanne R. Mathiasen - University of Kansas Medical CenterEdward S. Kimball - JanssenJeffrey L. Vaught - Cephalon, Inc., West Chester, PA, USA
- Publication Details
- Life Sciences, v 52(1), pp 1-8
- Publisher
- Elsevier; OXFORD
- Number of pages
- 8
- Resource Type
- Review
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1993KA87400001
- Scopus ID
- 2-s2.0-0027186703
- Other Identifier
- 991021900615604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy